| Sylvia Sidney | Joan Graham |
| Henry Fonda | Eddie Taylor |
| Barton MacLane | Stephen Whitney |
| Jean Dixon | Bonnie Graham |
| William Gargan | Father Dolan |
| Jerome Cowan | Doctor Hill |
| Charles 'Chic' Sale | Ethan (as Chic Sale) |
| Margaret Hamilton | Hester |
| Warren Hymer | Buggsy |
| Guinn 'Big Boy' Williams | Roger (as Guinn Williams) |
| John Wray | Warden Wheeler |
| Walter De Palma | Monk Mendall |
| Earl Askam | Corridor Guard (uncredited) |
| Hooper Atchley | Teletype Operator (uncredited) |
| Allen Black | Baby Taylor (uncredited) |
| Stanley Blystone | Rafferty - Guard (uncredited) |
| Ward Bond | Casey - Guard (uncredited) |
| Wade Boteler | Pat - Policeman with Package (uncredited) |
| Al Bridge | Guard (uncredited) |
| Don Brodie | Compositor (uncredited) |
| Raymond Brown | Engineer (uncredited) |
| George Burton | Convict Waiter (uncredited) |
| Jack Carson | Attendant in First Gas Station (uncredited) |
| Jack Cheatham | Prison Hospital Guard (uncredited) |
| Russ Clark | Officer (uncredited) |
| David Clyde | Fireman (uncredited) |
| Shirley Coates | Ethel (uncredited) |
| Harry Cording | Guard (uncredited) |
| Hal Craig | Bank Guard (uncredited) |
| Edgar Dearing | State Trooper Firing Machine Gun (uncredited) |
| Mary Anne Durkin | Warden's 14-Year-Old Daughter (uncredited) |
| Dick Elliott | City Editor (uncredited) |
| Franklyn Farnum | Plainclothesman (uncredited) |
| James Flavin | State Trooper (uncredited) |
| Malcolm Graham | Warden's Secretary (uncredited) |
| Frank Hagney | Plainclothesman (uncredited) |
| Jonathan Hale | District Attorney (uncredited) |
| Al K. Hall | Man in Auto Court Office (uncredited) |
| Ben Hall | Messenger with Package (uncredited) |
| Chuck Hamilton | Armored Car Guard Unloading Money (uncredited) |
| Oscar 'Dutch' Hendrian | Williams' Assistant (uncredited) |
| Jack Herrick | Convict Watching Baseball Game (uncredited) |
| Herbert Heywood | Brakeman in Diner (uncredited) |
| Al Hill | Attendant in Second Gas Station (uncredited) |
| Earl 'Hap' Hogan | Trusty (uncredited) |
| Betty Ruth Huff | Eight-Year-Old Girl (uncredited) |
| Stanley King | Convict (uncredited) |
| Ethan Laidlaw | Tony aka Tommy - a Guard (uncredited) |
| Robert Lee | Jason (uncredited) |
| Stanley Mack | Male Nurse (uncredited) |
| Wally Maher | Attendant in Second Gas Station (uncredited) |
| Frank Mills | Man Telling Eddie of Phone Call (uncredited) |
| Roberta Mountjoy | Warden's Eight-Year-Old Daughter (uncredited) |
| Ted Oliver | State Trooper (uncredited) |
| William Pawley | Mr. Williams (uncredited) |
| Lee Phelps | Corridor Guard (uncredited) |
| James Pierce | Guard (uncredited) |
| Lon Poff | Halsey (uncredited) |
| Stanley Price | Sparks - Man in Diner (uncredited) |
| Mickey Rentschler | Ten-Year-Old Boy (uncredited) |
| William Ruhl | Guard (uncredited) |
| Allen D. Sewall | Chess-Playing Convict (uncredited) |
| Claire Sinclair | Mrs. Wheeler (uncredited) |
| Robert St. Angelo | Corridor Guard (uncredited) |
| Jean Stoddard | Stenographer (uncredited) |
| Henry Taylor | Kozderonas - Apple Vendor (uncredited) |
| Monte Vandergrift | Traffic Policeman (uncredited) |
| Max Wagner | Dan - Corridor Guard (uncredited) |
| Kathrin Clare Ward | Blonde Cook in Diner (uncredited) |
| E. Alyn Warren | Prison Chef (uncredited) |
| Lillian West | Mother (uncredited) |
| Charles C. Wilson | Police Inspector (uncredited) |
| Harry Wilson | Convict Watching Baseball Game (uncredited) |