| Fredric March | William Spence |
| Martha Scott | Hope Morris Spence |
| Beulah Bondi | Mrs. Lydia Sandow |
| Gene Lockhart | Preston Thurston |
| Elisabeth Fraser | Eileen Spence at Age 17 |
| Harry Davenport | Elias Samson |
| Laura Hope Crews | Mrs. Preston Thurston |
| Grant Mitchell | Clayton Potter |
| Moroni Olsen | Dr. John Romer |
| Frankie Thomas | Hartzell Spence at Age 18 |
| Jerome Cowan | Dr. Horrigan |
| Ernest Cossart | Mr. John E. Morris |
| Nana Bryant | Mrs. Morris |
| Carlotta Jelm | Eileen Spence at Age 11 |
| Peter Caldwell | Hartzell Spence at Age 10 |
| Casey Johnson | William Frazer Spence |
| Sarah Edwards | Mrs. Spicer (scenes deleted) |
| Dick Elliott | Casper Cullenbaugh (scenes deleted) |
| Sol Gorss | Panhandler (scenes deleted) |
| Tempe Pigott | Mrs. Dibble (scenes deleted) |
| Lottie Williams | (scenes deleted) |
| Dorothy Adams | Woman Behind Hope at Baptism (uncredited) |
| Joan Anderson | Child (uncredited) |
| Roscoe Ates | George Reynolds (uncredited) |
| Leah Baird | Undetermined Role (uncredited) |
| Clara Blandick | Mrs. 'Sister' Watkins (uncredited) |
| Hobart Bosworth | Richard Hardy Case (uncredited) |
| Jed Breslau | Child (uncredited) |
| Harlan Briggs | Druggist 'Mac' MacFarland (uncredited) |
| Virginia Brissac | Mrs. Jellison (uncredited) |
| Mary Brodel | Second Bride (uncredited) |
| Sonny Bupp | Boy (uncredited) |
| Chester Conklin | Man Crying During Baptism (uncredited) |
| Ted Crane | Child (uncredited) |
| Charles Drake | Second Bridegroom (uncredited) |
| Ann Edmonds | First Bride (uncredited) |
| Fern Emmett | Woman Gossip (uncredited) |
| Mary Field | Tallulah 'Lulu' Digby (uncredited) |
| Inez Gay | Undetermined Role (uncredited) |
| William Gould | Fire Chief (uncredited) |
| Creighton Hale | Church Usher (uncredited) |
| Charles Halton | Haskins (uncredited) |
| William S. Hart | Silent' Budd Marr (scenes from 'The Silent Man) (archive footage) (uncredited) |
| Herbert Heywood | Shopkeeper (uncredited) |
| Gertrude Hoffman | Elderly Woman (uncredited) |
| Olin Howland | Train Station Master (uncredited) |
| Payne B. Johnson | School Boy (uncredited) |
| Fred Kelsey | Train Conductor (uncredited) |
| Milton Kibbee | Alf McAfee (uncredited) |
| Mickey Kuhn | Boy (uncredited) |
| Harry Lewis | Boy (uncredited) |
| Vera Lewis | Mrs. Simpson (uncredited) |
| Audra Lindley | Mother (uncredited) |
| Cathy Lipps | (uncredited) |
| Betty Mack | Thurstons' Maid (uncredited) |
| Jean Maddox | First Mother (uncredited) |
| Hank Mann | Sam, Fireman Saving Books (uncredited) |
| Frank Marlowe | Soldier (uncredited) |
| Frank Mayo | Waiting Train Passenger (uncredited) |
| Robert McKim | Handsome Jack Pressley (archive footage) (uncredited) |
| Mira McKinney | Movie Theater Cashier (uncredited) |
| Bess Meyers | Undetermined Role (uncredited) |
| Harold Miller | Second Clerk (uncredited) |
| Jack Mower | Man Behind Hope at Baptism (uncredited) |
| George Nichols | Prechin' Bill Hardy (archive footage) (uncredited) |
| Jane Randolph | Mother (uncredited) |
| Gus Reed | Choir Member (uncredited) |
| Frank Reicher | Board Member (uncredited) |
| Sam Rice | Man Quieting Boys in Theater (uncredited) |
| Ruth Robinson | Lydia's Maid (uncredited) |
| Virginia Sale | Sister Sale at the Movie Theater (uncredited) |
| Sandy Shaw | Child (uncredited) |
| Reginald Simpson | Candy Butcher (uncredited) |
| Walter Soderling | Parishiner Wanting More Sin in Sermon (uncredited) |
| Charlotte Treadway | Ella Hodges (uncredited) |
| Paula Trueman | Miss Peabody (uncredited) |
| Joyce Tucker | Girl (uncredited) |
| Dorothy Vaughan | Mrs. Ehrlich (uncredited) |
| Tom Wilson | Fireman Angus (uncredited) |
| Gig Young | First Groom Asking for Dog Licence (uncredited) |
