| Spencer Tracy | Sam Craig |
| Katharine Hepburn | Tess Harding |
| Fay Bainter | Ellen Whitcomb |
| Reginald Owen | Clayton |
| Minor Watson | William J. Harding |
| William Bendix | 'Pinkie' Peters |
| Gladys Blake | Flo Peters |
| Dan Tobin | Gerald Howe |
| Roscoe Karns | Phil Whittaker |
| William Tannen | Ellis |
| Ludwig Stössel | Dr. Lubbeck (as Ludwig Stossel) |
| Sara Haden | Matron |
| Edith Evanson | Alma |
| George Kezas | Chris |
| Jimmy Ames | Cab Driver (uncredited) |
| Herbert Ashley | Stage Doorman (uncredited) |
| Dorothy Ates | Phone Girl (uncredited) |
| Brooks Benedict | Clayton's Secretary (uncredited) |
| John Berkes | Pal (uncredited) |
| Symona Boniface | Tess' Party Guest (uncredited) |
| Elfriede Borodin | Leni (uncredited) |
| Jack Carr | Baseball Spectator Behind Tess (uncredited) |
| Ruth Cherrington | Foreigner (uncredited) |
| Ann Codee | Madame Sylvia (uncredited) |
| Jimmy Conlin | Reporter at Bar (uncredited) |
| Jules Cowles | Joe the Bartender (uncredited) |
| Floyd Criswell | Policeman (uncredited) |
| Fern Emmett | Justice of the Peace's Wife (uncredited) |
| Curt Furburg | Foreigner (uncredited) |
| Lisa Golm | Yugoslav Consul's Wife (uncredited) |
| George Guhl | Door Attendant (uncredited) |
| Winifred Harris | Chairlady (uncredited) |
| Carey Harrison | Spaniard (uncredited) |
| Bern Hoffman | Hindu Man at Party (uncredited) |
| William Holmes | Man at Banquet (uncredited) |
| Bobby Larson | Dickie Dunlap (uncredited) |
| Ben Lessy | Punchy (uncredited) |
| Murdock MacQuarrie | Head Copy Reader (uncredited) |
| Edward McWade | Adolph (uncredited) |
| Frank Mills | Mug (uncredited) |
| Gerald Mohr | Radio Emcee (uncredited) (voice) |
| Amber Norman | Showgirl (uncredited) |
| Sergio Orta | Mr. Yes (uncredited) |
| George Ovey | Little Sports Reporter (uncredited) |
| Bob Perry | Referee (uncredited) |
| Jack Raymond | Mug (uncredited) |
| Cyril Ring | Mr. Harding's Chauffeur (uncredited) |
| Julian Rivero | Spaniard (uncredited) |
| Henry Roquemore | Marcus P. Calverton - Justice of the Peace (uncredited) |
| Cy Schindell | Pinkie's Listener in Bar (uncredited) |
| Harry Semels | Mug (uncredited) |
| John Sheehan | Red Face (uncredited) |
| Eddie Lou Simms | Champ (uncredited) |
| Walter O. Stahl | Yugoslav Consul (uncredited) |
| Charles Sullivan | Cabby (uncredited) |
| Ray Teal | Married Sports Reporter (uncredited) |
| Harry Tenbrook | Mug (uncredited) |
| Michael Visaroff | Russian Guest (uncredited) |
| Harry Wilson | Lubbeck's Bodyguard (uncredited) |
| Duke York | Football Player (uncredited) |
| Joe Yule | Building Superintendent (uncredited) |
