| Charles Coburn | Professor Henry Holmes |
| Alexander Knox | Woodrow Wilson |
| Geraldine Fitzgerald | Edith Bolling Galt |
| Thomas Mitchell | Joseph Tumulty |
| Ruth Nelson | Ellen Wilson |
| Cedric Hardwicke | Senator Henry Cabot Lodge (as Sir Cedric Hardwicke) |
| Vincent Price | William Gibbs McAdoo |
| William Eythe | George Felton |
| Mary Anderson | Eleanor Wilson |
| Ruth Ford | Margaret Wilson |
| Sidney Blackmer | Josephus Daniels |
| Madeleine Forbes | Jessie Wilson |
| Stanley Ridges | Dr. Cary Grayson |
| Eddie Foy Jr. | Eddie Foy |
| Charles Halton | Colonel House |
| Thurston Hall | Senator Edward H. 'Big Ed' Jones |
| J.M. Kerrigan | Edward Sullivan |
| James Rennie | Jim Beeker |
| Marcel Dalio | Premier Georges Clemenceau |
| Katherine Locke | Helen Bones |
| Stanley Logan | Robert Lansing, Secretary of State |
| Edwin Maxwell | William Jennings Bryan |
| Clifford Brooke | Prime Minister David Lloyd George |
| Tonio Selwart | Count Von Bernstorff |
| John Ince | Senator Watson |
| Charles Miller | Senator Bromfield |
| John J. Pershing | Himself (archive footage) (as General Pershing) |
| George Anderson | Secretary David F. Houston (uncredited) |
| Louis V. Arco | German Delegate (uncredited) |
| John Ardell | Minor Role (uncredited) |
| Walter Baldwin | Wilson Campaign Orator (uncredited) |
| Griff Barnett | Reporter (uncredited) |
| Robert Barrat | Edwin Meredith, Secretary of Agriculture (uncredited) |
| Felix Basch | Minor Role (uncredited) |
| Symona Boniface | White House Reception Guest (uncredited) |
| Eddie Borden | Missouri Delegate (uncredited) |
| Jess Lee Brooks | White House Servant from Georgia (uncredited) |
| Phyllis Brooks | Granddaughter (uncredited) |
| Tom Brown | Boy (uncredited) |
| Francis X. Bushman | Barnard Baruch (uncredited) |
| George M. Carleton | Senator (uncredited) |
| Harry Carter | Minor Role (uncredited) |
| David Cavendish | Secretary (uncredited) |
| Ken Christy | Alabama Speaker at Convention (uncredited) |
| Davison Clark | Champ Clark, Speaker of the House (uncredited) |
| Russ Clark | Minor Role (uncredited) |
| Ray Cooper | Secretary (uncredited) |
| Gino Corrado | Italian Restaurant Waiter (uncredited) |
| Mary Currier | Woman at Baseball Game (uncredited) |
| Guy D'Ennery | Minor Role (uncredited) |
| John Davidson | Princeton Team Doctor (uncredited) |
| Frank Dawson | Minor Role (uncredited) |
| Earle S. Dewey | Reporter (uncredited) |
| Marie Dressler | Herself, at WWI rally (archive footage) (uncredited) |
| Ralph Dunn | Senator Robert La Follette (uncredited) |
| Edward Earle | Reporter (uncredited) |
| Ben Erway | Reporter (uncredited) |
| Paul Everton | Judge Westcott (uncredited) |
| Douglas Fairbanks | Himself, at WWI rally (archive footage) (uncredited) |
| Edward Fielding | Minor Role (uncredited) |
| Antonio Filauri | Minor Role (uncredited) |
| Francis Ford | Hughes Campaign Orator (uncredited) |
| John Forrest | Reporter (uncredited) |
| William Forrest | Minor Role (uncredited) |
| Russell Gaige | Bainbridge Colby, Secretary of State (uncredited) |
| Gus Glassmire | Minor Role (uncredited) |
| Gibson Gowland | Senator (uncredited) |
| Jesse Graves | Minor Role (uncredited) |
| Jessica Grayson | Minor Role (uncredited) |
| Joseph J. Greene | Chief Justice Edward White (uncredited) |
| Reed Hadley | White House Usher (uncredited) |
| Sherry Hall | Reporter (uncredited) |
| Edith Hallor | Minor Role (uncredited) |
| John Hamilton | Man in Wilson's Office (uncredited) |
| Sam Harris | General Tasker Bliss (uncredited) |
| Dell Henderson | Minor Role (uncredited) |
| Charles Anthony Hughes | Minor Role (uncredited) |
| Gladden James | Minor Role (uncredited) |
| Al Jolson | Himself, at WWI rally (archive footage) (uncredited) |
| Edward Keane | Hughes Campaign Orator (uncredited) |
| Cy Kendall | Charles F. Murphy (uncredited) |
| King George V | Himself (archive footage) (uncredited) |
| Emmett King | Senator (uncredited) |
| Ralph Linn | Minor Role (uncredited) |
| Arthur Loft | Franklin Lane, Secretary of the Interior (uncredited) |
| George Macready | William McCombs (uncredited) |
| Aubrey Mather | Hughes' Butler (uncredited) |
| George Mathews | Army Sergeant (uncredited) |
| Larry McGrath | William B. Wilson, Secretary of Labor (uncredited) |
| Tom McGuire | New York Delegate (uncredited) |
| Paul McVey | Reporter (uncredited) |
| Robert Middlemass | Lindley M. Garrison, Secretary of War (uncredited) |
| Matt Moore | Albert S. Burleson, Postmaster General (uncredited) |
| Edward Mundy | Minor Role (uncredited) |
| Carroll Nye | Reporter (uncredited) |
| Frank O'Connor | New York Delegate (uncredited) |
| Anne O'Neal | Jennie - Maid (uncredited) |
| Frank Orth | Smith (uncredited) |
| Emory Parnell | Chairman of Democratic Committee (uncredited) |
| Mary Pickford | Herself, at WWI rally (archive footage) (uncredited) |
| Hilda Plowright | Rep. Jeanette Rankin (uncredited) |
| Isabel Randolph | Housekeeper (uncredited) |
| Otto Reichow | German Delegate (uncredited) |
| Grandon Rhodes | White House Reporter (uncredited) |
| Roy Roberts | Mr. Hoover - Chief White House Butler (uncredited) |
| Dewey Robinson | New Jersey Democratic Campaign Worker (uncredited) |
| Theodore Roosevelt | Himself (archive footage) (uncredited) |
| Edward Ryan | Soldier Served Coffee by the President (uncredited) |
| Jeffrey Sayre | Shoeshine Customer (uncredited) |
| Harold Schlickenmayer | Minor Role (uncredited) |
| Scott Seaton | Senator (uncredited) |
| Harry Semels | Man Seated Next to Judge Everton (uncredited) |
| Jameson Shade | John Payne, Secretary of the Interior (uncredited) |
| C. Montague Shaw | Harry L. White (uncredited) |
| Reginald Sheffield | Newton D. Baker, Secretary of War (uncredited) |
| Arthur Space | Francis Sayre (uncredited) |
| Jack Stoney | Reporter (uncredited) |
| Ferris Taylor | Missouri Speaker at Convention (uncredited) |
| Forrest Taylor | Wilson Campaign Orator (uncredited) |
| Harry Tyler | Streetcar Conductor (uncredited) |
| John Whitney | Minor Role (uncredited) |
| Ian Wolfe | Reporter (uncredited) |
| Will Wright | Hughes Campaign Orator in Maine (uncredited) |
| William Yetter Sr. | German Delegate (uncredited) |
