| John Wayne | Lt Cmdr. Duke E. Gifford |
| Patricia Neal | Lt. (j.g.) Mary Stuart |
| Ward Bond | Cmdr. John T. 'Pop' Perry |
| Scott Forbes | Lt. Larry |
| Philip Carey | Lt. (j.g.) Bob Perry |
| Paul Picerni | Jonesy |
| William Campbell | The Talker (as Bill Campbell) |
| Kathryn Givney | Cmdr. Steele |
| Martin Milner | Ens. Caldwell |
| Cliff Clark | Commander, SUBPAC |
| Jack Pennick | The Chief |
| Virginia Brissac | Sister Anna |
| Vincent Fotre | Soundman |
| Lewis Martin | Squad Commander |
| Sam Edwards | Junior |
| Louis Mosconi | Radarman Mosconi |
| John Baer | Fighter Pilot (uncredited) |
| Robert Carson | Torpedo Officer (uncredited) |
| Gail Davis | Bit Part (uncredited) |
| Chris Drake | Sparks - Radioman (uncredited) |
| James Flavin | Mick - SP Commander (uncredited) |
| Bess Flowers | Dance Floor Extra (uncredited) |
| Ray Hyke | Crewman (uncredited) |
| Gayle Kellogg | Crewman (uncredited) |
| Al Kikume | Hawaiian (uncredited) |
| Brett King | Lt. Ernie Stark (uncredited) |
| Mike Lally | Quartermaster (uncredited) |
| Keith Larsen | Crewman (uncredited) |
| Harry Lauter | Freddie - Officer on Submarine Corvena) (uncredited) |
| Richard Loo | Japanese Fighter Pilot (uncredited) |
| Bob Nash | Quartermaster (uncredited) |
| Carl Saxe | Shore Patrolman (uncredited) |
| William Self | Helmsman (uncredited) |
| Michael St. Angel | Lt. Jorgenson (uncredited) |
| Bert Stevens | Naval Officer at Briefing (uncredited) |
| Milburn Stone | Ground Control Officer (uncredited) |
| Harlan Warde | Dick - Admiral's Aide (uncredited) |
| Steve Wayne | Crewman (uncredited) |
| Mack Williams | Crewman (uncredited) |
| Carleton Young | Pilot Briefing Officers on Carrier (uncredited) |