| Tony Danza | Tony Micelli (196 episodes, 1984-1992) |
| Judith Light | Angela Bower (196 episodes, 1984-1992) |
| Alyssa Milano | Samantha Micelli (196 episodes, 1984-1992) |
| Danny Pintauro | Jonathan Bower (196 episodes, 1984-1992) |
| Katherine Helmond | Mona Robinson (196 episodes, 1984-1992) |
| Rhoda Gemignani | Mrs. Rossini (25 episodes, 1984-1992) |
| Shana Lane-Block | Bonnie (22 episodes, 1985-1992) |
| Jonathan Halyalkar | William 'Billy' Napoli (21 episodes, 1990-1991) |
| Ralph P. Martin | Ernie (10 episodes, 1989-1992) |
| Billy Gallo | Al (9 episodes, 1989-1992) |
| Curnal Achilles Aulisio | Hank Thomopolous (9 episodes, 1992) |
| Nicole Eggert | Marci Ferguson (7 episodes, 1985-1986) |
| Angela Lee | Julia (7 episodes, 1985-1987) |
| Robin Thomas | Geoffrey Wells (6 episodes, 1986-1987) |
| Scott Bloom | Jesse Nash (6 episodes, 1987-1988) |
| Earl Boen | Jim Petersen (5 episodes, 1984-1986) |
| Dori Brenner | Wendy Wittener (5 episodes, 1985-1987) |
| Colette Duvall | Airline Agent / ... (5 episodes, 1990-1992) |
| Candice Azzara | Fran Thomopolous (5 episodes, 1992) |
| Vic Polizos | Joe Thomopolous (5 episodes, 1992) |
| James Naughton | Michael Bower (4 episodes, 1985) |
| Jim Jansen | Dr. Doyle Ferguson (4 episodes, 1985-1986) |
| Howard Stevens | Howie Mendelson (4 episodes, 1985-1986) |
| John Del Regno | Philly Fingers (4 episodes, 1986-1989) |
| Walter Olkewicz | Tiny McGee / ... (4 episodes, 1987-1992) |
| Doug Ballard | Andy (4 episodes, 1990) |
| Kate Vernon | Kathleen Sawyer (4 episodes, 1990) |
| James Coco | Nick Milano (3 episodes, 1985-1987) |
| Christopher Burton | Steven (3 episodes, 1985-1986) |
| Frank Pesce | Dave / ... (3 episodes, 1985-1992) |
| Adam Carl | Mason (3 episodes, 1987-1989) |
| Vinny Argiro | Vinnie / ... (3 episodes, 1986-1992) |
| Bill Erwin | Leon / ... (3 episodes, 1984-1987) |
| Josh Byrne | Joey (3 episodes, 1990-1991) |
| Keri Houlihan | Jenny Wittener (3 episodes, 1985-1987) |
| Tonya Crowe | Robin Fraser (3 episodes, 1985-1986) |
| Pamela Galloway | Joanne Parker (3 episodes, 1986-1988) |
| Robert Briscoe Evans | Announcer / ... (3 episodes, 1988-1992) |
| Ria Giullani | Abbie / ... (3 episodes, 1990-1992) |
| Pat Buttram | Chappy (3 episodes, 1990-1991) |
| Ross Malinger | Rory / ... (3 episodes, 1990-1991) |
| Tom Troupe | Father Marconi (3 episodes, 1990-1991) |
| Jerry Hardin | Dr. Graham (3 episodes, 1992) |
| Rosie Taravella | Flight Attendant / ... (3 episodes, 1992) |
| Scott Grimes | Chad McCann (2 episodes, 1986-1987) |
| Vito Scotti | Uncle Aldo / ... (2 episodes, 1985-1988) |
| Ray 'Boom Boom' Mancini | Joey Rossini (2 episodes, 1985-1986) |
| Joe Regalbuto | Don / ... (2 episodes, 1986-1987) |
| Todd Jeffries | Minister / ... (2 episodes, 1985-1987) |
| Paul Sand | Packard / ... (2 episodes, 1985-1987) |
| Richard Sanders | Bob Wormser (2 episodes, 1985) |
| Betty White | Bobby Barnes / ... (2 episodes, 1985) |
| Leslie Nielsen | Max Muldoon (2 episodes, 1987-1988) |
| Sam McMurray | Mark / ... (2 episodes, 1989-1991) |
| Vincent Schiavelli | Motel Manager (2 episodes, 1985) |
| Antonia Rey | Aunt Rosa (2 episodes, 1988-1990) |
| Leah Ayres | Pam / ... (2 episodes, 1989-1991) |
| James Hampton | Herb / ... (2 episodes, 1984-1985) |
| Troy W. Slaten | David (2 episodes, 1985) |
| Michael Keys Hall | Mike McCann / ... (2 episodes, 1986-1987) |
| Phil Rubenstein | Phil / ... (2 episodes, 1986-1987) |
| Todd Starks | Hardhat / ... (2 episodes, 1987-1988) |
| Matty Danza | Marty / ... (2 episodes, 1986-1991) |
| Fran Drescher | Carol Patrice / ... (2 episodes, 1985-1986) |
| Fern Fitzgerald | Dr. Isabel Schaeffer (2 episodes, 1985-1986) |
| Suzanne Barnes | Heather (2 episodes, 1985) |
| Dennis Burkley | Pee Wee (2 episodes, 1986-1989) |
| Dale Raoul | Miss Olive / ... (2 episodes, 1986) |
| Beau Billingslea | Chef / ... (2 episodes, 1987) |
| Charles Gideon Davis | Jimbo (2 episodes, 1988-1991) |
| John Hostetter | Satch (2 episodes, 1988-1991) |
| Harvey Shield | D.J. (2 episodes, 1988-1991) |
| Bobby Brett | Gene / ... (2 episodes, 1988-1989) |
| Chelsea Noble | Cynthia (2 episodes, 1988-1989) |
| Alan Oppenheimer | Dean Brown (2 episodes, 1988-1989) |
| Pat Sturges | Liz / ... (2 episodes, 1989-1991) |
| Mary Cadorette | Deb (2 episodes, 1989-1990) |
| Randee Heller | Carol (2 episodes, 1989-1990) |
| Tara Karsian | Debbie / ... (2 episodes, 1989-1990) |
| Michael Learned | Trish Carlin (2 episodes, 1989) |
| Leah Remini | Charlie Briscoe (2 episodes, 1989) |
| Richie Rosati | Alex (2 episodes, 1989) |
| Chris Paul Davis | Christopher / ... (2 episodes, 1990-1991) |
| Dale Harimoto | Laurie Lee (2 episodes, 1990-1991) |
| Jennifer McComb | Jennifer (2 episodes, 1990-1991) |
| Oliver Muirhead | Maitre d' / ... (2 episodes, 1990-1991) |
| Ria Pavia | Laurie (2 episodes, 1990-1991) |
| Stan Ivar | Peter Gerber (2 episodes, 1990) |
| Patrick Muldoon | Matt (2 episodes, 1990) |
| Naomi Serotoff | Mrs. Laudicina / ... (2 episodes, 1990) |
| Eileen Barnett | Elaine Braddock (2 episodes, 1991-1992) |
| Lisa Cohen | Cheerleader #1 / ... (2 episodes, 1991-1992) |
| Bruce French | Ted Braddcock / ... (2 episodes, 1991-1992) |
| Robert Mandan | Reed Hamilton / ... (2 episodes, 1991-1992) |
| Dick Christie | Ben (2 episodes, 1991) |
| Franklin Cover | Mr. Campell / ... (2 episodes, 1991) |
| Mimi Cozzens | Senator Mars (2 episodes, 1991) |
| Robin Jameson | Lisa (2 episodes, 1991) |
| Jeff Austin | Security Guard / ... (2 episodes, 1992) |
| Frances Bay | Candy (2 episodes, 1992) |
| Charmaine Charles | Flight Attendant #2 / ... (2 episodes, 1992) |
| Pat Millicano | Ned (2 episodes, 1992) |
