| John Putch | Danny Stubbs |
| Terry Beaver | William Miller |
| Brad Dourif | Kevin Harrington |
| Lane Davies | Steve Barrett |
| Benji Wilhoite | Young Bill Miller |
| J.J. Sacha | Young Danny Stubbs |
| Sam McPhaul | Young Kevin Harrington |
| Jason Jones | Young Steve Barrett |
| Mary Nell Santacroce | Sister Gertrude |
| Mary Beth McDonough | Sister Juliet |
| Sandra Dorsey | Sister Othilda |
| Randi Layne | Sister Joan of Arc |
| Muriel Moore | Sister Edmunda |
| Carol Haynes | Sister Scholastica |
| Donna Smith | Sister Atta |
| Judith Anderson | The Sister of Purgatory (voice) |
| Joe Conley | Father Minnelli |
| Dennis Harrington | Father O'Neill |
| Bob Bost | Father Morgan |
| Charlie Hill | Bill Miller Sr. |
| Shirlene Foss | Mildred Miller |
| Carmen Thomas | Marie Borkowsky |
| Jeff Benninghofen | Peterson |
| Tiffanie Shay | Mary Lou |
| Stan Wakefield | Quarterback |
| Kirk Smith | Defensive Back / Adult Football Player (as Kirk K. Smith) |
| Bob Flor | John F. Kennedy (voice) |
| Jeff McCartney | Radio Announcer (voice) |
| Angela Shore | Mary Mullins |
| Andriyel Poymer | Susie Crutchfield / Second Grade Communion |
| Eleanor Jones | Patty Stubbs / St. Jude Student |
| Katie Landers | Diane Miller |
| Sara Buda | Joanie / St. Jude Student |
| Randal Patrick | Master of Ceremonies |
| Rob Cleveland | Man #1 |
| Lon Slack | Man #2 (as Lon M. Slack) |
| Debbie Atkinson | Bill's Wife |
| Matthew Giles | Football Bully |
| Darnell Brown | Football Bully |
| Delta Brown | Football Bully |
| Peter Birdsey | Young Football Player / St. Jude Student |
| Colin Bragg | Young Football Player |
| Jason Broome | Young Football Player |
| Jay Brown | Young Football Player / Second Grade Communion |
| Chris Clayton | Young Football Player |
| Giles Cohen | Young Football Player |
| Lamar Doso | Young Football Player |
| Asa Fain | Young Football Player |
| Kenneth Forsythe | Young Football Player / Second Grade Communion |
| Ray Forsythe | Young Football Player / Second Grade Communion |
| Mark Giles | Young Football Player |
| Todd Grimm | Young Football Player |
| Molly Malloy | Young Football Player / St. Jude Student |
| Mike Ory | Young Football Player / St. Jude Student |
| Brad Sharp | Young Football Player |
| Warren Speakes | Young Football Player / St. Jude Student |
| Brandon Tucker | Young Football Player |
| John N. Davis | Adult Football Player |
| James Doyle | Adult Football Player |
| Frank Ferree | Adult Football Player |
| Rick Gaines | Adult Football Player |
| Peter Hussings | Adult Football Player |
| Richard Johnson | Adult Football Player |
| Chet Koenig | Adult Football Player |
| Ken Kubinski | Adult Football Player |
| Terry Malloy | Adult Football Player |
| Fred Mayfield | Adult Football Player |
| Chris Russell | Adult Football Player |
| Bob Shore | Adult Football Player |
| Ricky Shore | Adult Football Player |
| Jerry Silva | Adult Football Player |
| Kirk Smith Jr. | Adult Football Player |
| Art Speakes Jr. | Adult Football Player |
| Dick Wood | Adult Football Player |
| Vickie Ackerman | St. Jude Student |
| Lee Adams | St. Jude Student |
| Bengt Allen | St. Jude Student |
| Dana Ahrenholz | St. Jude Student |
| Jay Barnett | St. Jude Student |
| Tom Barnett | St. Jude Student |
| Jay Barron | St. Jude Student |
| Kim Barron | St. Jude Student |
| Tanya Bell | St. Jude Student |
| Matt Blodgett | St. Jude Student |
| Laura Branford | St. Jude Student |
| George Brenick | St. Jude Student |
| Elizabeth Bryant | St. Jude Student |
| Rachel Christian | St. Jude Student / Second Grade Communion |
| Carolyn Church | St. Jude Student |
| Sabrina Church | St. Jude Student |
| Valerie Crane | St. Jude Student |
| John Deandrade | St. Jude Student |
| Lester Dragstedt | St. Jude Student |
| Taylor Eason | St. Jude Student |
| Jessie Friedlander | St. Jude Student |
| Kevin J. Foxe | St. Jude Student (as Kevin Foxe) |
| Alyson Hannigan | Patty Stubbs (as Allison Hannigan) |
| Missie Hill | St. Jude Student |
| Stacy Hines | St. Jude Student |
| Julie Hunt | St. Jude Student |
| Darrell Jobe | St. Jude Student |
| Margaret Jones | St. Jude Student |
| Rufus Jones | St. Jude Student |
| Kenny Kopp | St. Jude Student |
| Jenny Lamb | St. Jude Student |
| Dierdre Mott | St. Jude Student |
| Jim Mulkey | St. Jude Student |
| Maria Nagy | St. Jude Student |
| Jill Ory | St. Jude Student |
| Cathy Scaggs | St. Jude Student |
| Jennifer Scaggs | St. Jude Student |
| Sarah Scaggs | St. Jude Student |
| Summer Shohfi | St. Jude Student (as Cheryl Shohfi) |
| Katie Skeen | St. Jude Student |
| Greg Smith | St. Jude Student |
| Kelsy Smith | St. Jude Student |
| Lester Smith | St. Jude Student |
| Janel Stover | St. Jude Student |
| Howie Stepp | St. Jude Student |
| Jesse Bastien | Second Grade Communion |
| Sarah Bates | Second Grade Communion |
| Brittney Blevins | Second Grade Communion |
| Alison Calloway | Second Grade Communion |
| Craig Calloway | Second Grade Communion |
| Erin Calloway | Second Grade Communion |
| Molly Christian | Second Grade Communion |
| Sue Curran | Second Grade Communion |
| Joshua Dubose | Second Grade Communion |
| Kevin Dubose | Second Grade Communion |
| Kimberly Dubose | Second Grade Communion |
| Keith Ferris | Second Grade Communion |
| Deena Fields | Second Grade Communion |
| Chip Coffey | Steve's Boyfriend (uncredited) (voice) |
