| Mike Myers | Wayne Campbell |
| Dana Carvey | Garth Algar |
| Christopher Walken | Bobby Cahn |
| Tia Carrere | Cassandra Wong |
| Chris Farley | Milton |
| Ralph Brown | Del Preston |
| James Hong | Jeff Wong |
| Rip Taylor | Himself |
| Steven Tyler | Himself - Aerosmith Singer |
| Joe Perry | Himself - Aerosmith Guitarist (as Joseph Perry) |
| Brad Whitford | Himself - Aerosmith Guitarist |
| Tom Hamilton | Himself - Aerosmith Bassist (as Thomas Hamilton) |
| Joey Kramer | Himself - Aerosmith Drummer (as Joseph Kramer) |
| Lee Tergesen | Terry |
| Dan Bell | Neil |
| Richard Epper | Guy at Concert |
| Jenny McShane | Girl at Concert (as Jennifer Miller) |
| Duke Valenti | Security Guy |
| Benny Graham | Security Guy |
| Gavin Grazer | Scott |
| Googy Gress | Gate Security Guy |
| Heather Locklear | Herself |
| Bob Odenkirk | Concert Nerd |
| Robert Smigel | Concert Nerd |
| Larry Sellers | Naked Indian |
| Michael A. Nickles | Jim Morrison |
| Joe Liss | Chicken Guy |
| Bobby Slayton | Watermelon Guy |
| George Foster | Lead Guitarist |
| Paul Raczkowski | Recording Engineer |
| Frank DiLeo | Frankie 'Mr. Big' Sharp |
| Sydney Coberly | Mikita's Waitress |
| Kevin Pollak | Jerry Segel |
| Olivia d'Abo | Betty Jo |
| Kim Basinger | Honey Horneé |
| Ron Litman | Tool Box DJ |
| Matthew Kenna | Roadie |
| Sean Michael Guess | Roadie |
| Drew Barrymore | Bjergen Kjergen |
| Harry Shearer | Handsome Dan |
| Ted McGinley | Mr. Scream |
| Tim Meadows | Sammy Davis, Jr. |
| Scott Coffey | Heavy Metaller |
| Lance Edwards | Heavy Metaller |
| Jay Leno | Himself |
| Al Hansen | Bad Actor |
| Charlton Heston | Good Actor |
| Bob Larkin | Wedding Minister |
| Ed O'Neill | Glen, Mikita's Manager |
| James Downey | Jeff Wong (voice) |
| Jaime Campos | Concert Rocker (uncredited) |
| Carlo Corazon | Aerosmith Fan at the Concert (uncredited) |
| Priscilla Cory | Pretty Brunette at Concert (uncredited) |
| Ryal Haakenson | Wedding Guest (uncredited) |
| Nash Kato | Musician exiting Limo (uncredited) |
| Bob Pepper | Mosh-Pit Rocker (uncredited) |
| 'Diamond' Tim Pleshaw | Waynestock Fan (uncredited) |
| Stevie Rachelle | Rocker (uncredited) |
| Gina Roland | Hostess at Comrade's (uncredited) |
| Stephen Surjik | Director (uncredited) |
| Shawn Wilson | Security Guard (uncredited) |
