| Kevin Costner | Wyatt Earp |
| Dennis Quaid | Doc Holliday |
| Gene Hackman | Nicholas Earp |
| David Andrews | James Earp |
| Linden Ashby | Morgan Earp |
| Jeff Fahey | Ike Clanton |
| Joanna Going | Josie Marcus |
| Mark Harmon | Sheriff Johnny Behan |
| Michael Madsen | Virgil Earp |
| Catherine O'Hara | Allie Earp |
| Bill Pullman | Ed Masterson |
| Isabella Rossellini | Big Nose Kate |
| Tom Sizemore | Bat Masterson |
| JoBeth Williams | Bessie Earp |
| Mare Winningham | Mattie Blaylock |
| James Gammon | Mr. Sutherland |
| Rex Linn | Frank McLaury |
| Randle Mell | John Clum |
| Adam Baldwin | Tom McLaury |
| Annabeth Gish | Urilla Sutherland |
| Lewis Smith | Curly Bill Brocius |
| Ian Bohen | Young Wyatt |
| Betty Buckley | Virginia Earp |
| Alison Elliott | Lou Earp |
| Todd Allen | Sherm McMasters |
| Mackenzie Astin | Francis O'Rourke |
| Jim Caviezel | Warren Earp |
| Karen Grassle | Mrs. Sutherland |
| John Dennis Johnston | Frank Stillwell (as John Denis Johnston) |
| Téa Leoni | Sally |
| Martin Kove | Ed Ross |
| Jack Kehler | Bob Hatch |
| Kirk Fox | Pete Spence |
| Norman Howell | Johnny Ringo |
| Boots Southerland | Marshal Fred White |
| Scotty Augare | Indian Charlie |
| Gabriel Folse | Billy Clanton |
| Kris Kamm | Billy Claiborne |
| John Lawlor | Judge Spicer |
| Monty Stuart | Dutch Wiley |
| Hugh Ross | Erwin Sutherland |
| Gregory Avellone | Traveler |
| Michael McGrady | John Shanssey |
| Mary Jo Niedzielski | Martha Earp |
| Scott Paul | Young Morgan |
| Oliver Hendrickson | Young Warren |
| Darwin Mitchell | Tom Chapman |
| Steve Kniesel | Bullwacker |
| Larry Sims | Dirty Sodbuster |
| Greg Goossen | Friend of Bullwacker |
| Heath Kizzier | Red |
| Clark Sanchez | Mike Donovan |
| Ed Beimfohr | Faro Dealer |
| Giorgio E. Tripoli | Judge Earp |
| Ben Zeller | Dr. Seger |
| Rockne Tarkington | Stable Hand |
| Scott Rasmussen | Minister |
| Ellen Blake | Paris |
| Steph Benseman | Pine Bluff Sheriff |
| Bob 'Dutch' Holland | Tubercular Inmate |
| Steve Cormier | Tent Saloon Bartender |
| Matt Langseth | Link Borland |
| David Doty | Mayor Wilson |
| Steven Gregory Tyler | Deputy Ford (as Steven G. Tyler) |
| Billy Streater | Marshal Mike Meagher |
| David L. Stone | Sheriff Larry Deger |
| Jake Walker | Mannen Clements |
| Matt O'Toole | Gyp Clements |
| Geo Cook | Big Cowboy |
| Dillinger Steele | Drunk Cowboy |
| Steve Lindsay | Drunk Cowboy |
| Dick Beach | Wagner |
| Benny Manning | Walker |
| Kathleen O'Hara | Hotel Resident |
| Nick Benseman | Delivery Boy (as Nicholas Benseman) |
| Sarge McGraw | Deputy Black |
| Luce Rains | Spangenberg (as Steven Hartley) |
| Brett Cullen | Saddle Tramp |
| Marlene D. Williams | Saloon Dealer (as Marlene Williams) |
| Paul Ukena | Bar regular |
| Owen Roizman | Danny |
| Karen Schwartz | Marshal White's Wife |
| Glen Burns | Bar Patron |
| John Furlong | Clem Hafford |
| Zack McGillis | Rancher |
| Adam Taylor | Texas Jack |
| Rusty Hendrickson | Turkey Creek Jack |
| Hanley Smith | Billiard Parlor Patron |
| Jon Kasdan | Bar Boy |
| Dale West | Station Master |
| Michael Huddleston | Albert |
| Albert Trujillo | Camp Foreman (as Al Trujillo) |
| John Doe | Tommy Behind-the-Deuce |
| Matt Beck | McGee |
| Gary Dueer | Dirk Gird |
| Joe Bernier | Fast Draw Cowboy (uncredited) |
| Ivan Brutsche | Cavalry Captain (uncredited) |
| Bryan David Wright | Young Boy (uncredited) |
| Shannon Denton | Man with Whores (uncredited) |
| Elias Gallegos | Horseback Outlaw (uncredited) |
| Lawrence Kasdan | Gambler (uncredited) |
| Tanit Lee Lascelles | Townsperson (uncredited) |
| James 'JR' Pollard | Carpetbagger in Saloon (uncredited) |
| John Pritchett | The Drummer (uncredited) |
| Mark Thomason | Cowboy at Table (uncredited) |
| Tracy Weisert | Buttercup (uncredited) |
| Jim Wilson | Doctor for Virgil Earp (uncredited) |
