| Mike Judge | Hank Hill / ... (258 episodes, 1997-2010) |
| Kathy Najimy | Peggy Hill / ... (258 episodes, 1997-2010) |
| Pamela Adlon | Bobby Hill / ... (258 episodes, 1997-2010) |
| Johnny Hardwick | Dale Gribble / ... (257 episodes, 1997-2010) |
| Stephen Root | Bill Dauterive / ... (257 episodes, 1997-2010) |
| Brittany Murphy | Luanne Platter / ... (231 episodes, 1997-2009) |
| Toby Huss | Kahn Souphanousinphone, Sr. / ... (150 episodes, 1997-2010) |
| David Herman | Buckley / ... (146 episodes, 1997-2010) |
| Ashley Gardner | Nancy Hicks Gribble / ... (125 episodes, 1997-2010) |
| Lauren Tom | Minh Souphanousinphone / ... (98 episodes, 1997-2010) |
| Breckin Meyer | Joseph Gribble / ... (60 episodes, 2000-2010) |
| Dennis Burkley | Principal Moss / ... (35 episodes, 1997-2010) |
| Jonathan Joss | John Redcorn / ... (34 episodes, 1997-2009) |
| Scott Klace | Additional Voices / ... (31 episodes, 2004-2009) |
| Tom Petty | Lucky / ... (28 episodes, 2004-2009) |
| Phil Hendrie | Little John / ... (24 episodes, 1999-2009) |
| Phil LaMarr | Roger 'Booda' Sack / ... (18 episodes, 1999-2009) |
| Danny Trejo | Enrique / ... (17 episodes, 2003-2010) |
| James Sie | Nguc Phong / ... (12 episodes, 2002-2008) |
| Glenn L. Lucas | Surf Kid / ... (11 episodes, 1999-2009) |
| Beth Grant | Nurse / ... (11 episodes, 1998-2010) |
| Dave Thomas | Lane Pratley / ... (11 episodes, 1998-2005) |
| Chuck Mangione | Himself (10 episodes, 1997-2003) |
| Randal Reeder | Customer / ... (9 episodes, 2005-2007) |
| Joanna Gleason | Maddy Platter / ... (8 episodes, 1997-2004) |
| Maurice LaMarche | Reverend Thomason / ... (8 episodes, 1997-1999) |
| Fred Willard | Officer Brown / ... (7 episodes, 2001-2008) |
| Ashley Johnson | Emily / ... (7 episodes, 2004-2010) |
| Henry Gibson | Bob Jenkins / ... (7 episodes, 2005-2008) |
| Tara Strong | Billy / ... (6 episodes, 1998-2004) |
| Rini Bell | Jane / ... (5 episodes, 2007-2009) |
| Wyatt Cenac | Cameraman / ... (5 episodes, 2007-2008) |
| Chris Elliott | Chris Sizemore / ... (5 episodes, 2003-2008) |
| Cheryl Holliday | Randy Miller / ... (5 episodes, 1997-1999) |
| Paul Butcher | Kenny / ... (5 episodes, 2005-2008) |
| Jim Cummings | Bounty Hunter / ... (5 episodes, 1997-1998) |
| Billy West | Cigarenders Leader / ... (5 episodes, 1997-1999) |
| Mac Davis | Announcer / ... (5 episodes, 1999-2006) |
| Trace Adkins | Elvin / ... (5 episodes, 2003-2007) |
| Abby Elliott | Hipster Girl / ... (4 episodes, 2008) |
| Josh Keaton | (4 episodes, 2007-2009) |
| Marissa Jaret Winokur | Doreen / ... (4 episodes, 2007-2008) |
| Jennifer Coolidge | Miss Kremzer (4 episodes, 1997-1999) |
| Dave Allen | Appleseed / ... (4 episodes, 2002-2007) |
| Jillian Bowen | Lori / ... (4 episodes, 2006-2010) |
| Mo Collins | Carly / ... (4 episodes, 2005-2008) |
| Ernie Grunwald | Bookstore Cashier / ... (4 episodes, 2003-2009) |
| Glenn Morshower | Bud Ferguson / ... (4 episodes, 2005-2009) |
| Peri Gilpin | Gwen St. James / ... (4 episodes, 2003-2009) |
| John Ritter | Eugene Grandy (4 episodes, 1997-2004) |
| Castulo Guerra | Magistrate / ... (4 episodes, 1997-2001) |
| Amy Hill | Mrs. Kalaiki-Alii / ... (4 episodes, 1998-2003) |
| Jill Parker | Emily (4 episodes, 1999-2000) |
| Marcelo Tubert | Marty Mendez (4 episodes, 2001-2003) |
| Norwood Cheek | Speck / ... (4 episodes, 2003-2006) |
| Patrick Bristow | P.J. (3 episodes, 2007-2009) |
| Jeremy Suarez | Arrow Kid #1 / ... (3 episodes, 2007-2008) |
| Diedrich Bader | Dirk / ... (3 episodes, 1999-2009) |
| Steve Gunderson | (3 episodes, 2007-2008) |
| Mitchel Musso | Curt / ... (3 episodes, 2007) |
| Dax Shepard | Zack / ... (3 episodes, 2004-2008) |
| Andrea Bowen | Sandy / ... (3 episodes, 2006-2009) |
| Mary Kay Place | Helen Shell / ... (3 episodes, 1998-2009) |
| Justin Long | Adam / ... (3 episodes, 2006-2007) |
| Angela Kinsey | Angela (3 episodes, 1997-2002) |
| Bertila Damas | Maria Montalvo / ... (3 episodes, 1998-2008) |
| Eloy Casados | Enrique (3 episodes, 1998-1999) |
| Brian Doyle-Murray | Jack (3 episodes, 2000-2007) |
| K Callan | Tilly Hill (3 episodes, 2000-2003) |
| Lane Smith | Charlie Fortner / ... (3 episodes, 2000) |
| Kathleen Turner | Miss Liz Strickland (3 episodes, 2000) |
| Elizabeth Perkins | Jan Shaw / ... (3 episodes, 2002-2004) |
| Amy Adams | Merilynn / ... (3 episodes, 2004) |
| Georgina Cordova | (2 episodes, 2009) |
| Mikey Kelley | (2 episodes, 2007) |
| Jerry Lambert | J.J. Womack / ... (2 episodes, 2008-2009) |
| Lori Nasso | (2 episodes, 2009) |
| Victor Aaron | John Redcorn (2 episodes, 1997) |
| Earl Houston Bullock | Dave / ... (2 episodes, 1999) |
| Stephanie Darby | (2 episodes, 2004-2009) |
| Madeline Zima | (2 episodes, 2001) |
| Mary Scheer | Bank Teller / ... (2 episodes, 1997-2002) |
| Carl Reiner | Garry Kasner / ... (2 episodes, 1997-2000) |
| Dawnn Lewis | Sharona Johnson (2 episodes, 1997-1999) |
| Dan Butler | Attorney / ... (2 episodes, 1997-1998) |
| Brent Forrester | Dealer / ... (2 episodes, 1997-1998) |
| Tammy Wynette | Tilly Hill (2 episodes, 1997-1998) |
| Neil Giuntoli | Closer #2 / ... (2 episodes, 1997) |
| Jim Dauterive | Cockroach / ... (2 episodes, 1998-2001) |
| J. Evan Bonifant | (2 episodes, 1998-1999) |
| Betty White | Delia / ... (2 episodes, 1999-2002) |
| Chelcie Ross | Councilman Fred Ebberd (2 episodes, 1999-2001) |
| Clint Black | Chad / ... (2 episodes, 1999-2000) |
| Dena Dietrich | Marge / ... (2 episodes, 1999) |
| Jane Wiedlin | Kate (2 episodes, 1999) |
| Brendan Fraser | David Kalaiki-Alii / ... (2 episodes, 2000-2005) |
| Charlie Daniels | Himself (2 episodes, 2000-2002) |
| Vince Gill | Assistant Pastor Larry / ... (2 episodes, 2000-2002) |
| Kathryn Harrold | Mother Superior / ... (2 episodes, 2000-2002) |
| Andrew Lawrence | Rodeo Kid (2 episodes, 2000) |
| Reese Witherspoon | Debbie (2 episodes, 2000) |
| Edward Asner | Stinky (2 episodes, 2001-2002) |
| Jack Carter | Irwin Linker (2 episodes, 2001-2002) |
| Anna Faris | Lisa / ... (2 episodes, 2002-2004) |
| Laura Dern | Katherine / ... (2 episodes, 2002-2003) |
| Ruth Livier | Cristina / ... (2 episodes, 2003-2005) |
| Bru Muller | Big Jock / ... (2 episodes, 2003-2005) |
| Tony Denman | Benji / ... (2 episodes, 2003-2004) |
| Nicky Katt | Artist / ... (2 episodes, 2003-2004) |
| Jamie Kennedy | Dr. Tim Rast / ... (2 episodes, 2003-2004) |
| Monica Keena | Bartender / ... (2 episodes, 2003) |
| Romy Rosemont | Margo (2 episodes, 2004-2010) |
| Danica McKellar | Misty / ... (2 episodes, 2004) |
| Timm Sharp | Man with Snake / ... (2 episodes, 2005) |
| Johnny Knoxville | Hoyt Platter / ... (2 episodes, 2006-2008) |
