| Bette Midler | Jacqueline Susann |
| Nathan Lane | Irving Mansfield |
| Stockard Channing | Florence Maybelle |
| David Hyde Pierce | Michael Hastings |
| John Cleese | Henry Marcus |
| John Larroquette | Maury Manning |
| Amanda Peet | Debbie |
| Terrence Ross | Radio actor |
| Jeffrey Ross | Shecky |
| Christopher McDonald | Brad Bradburn (as Christopher MacDonald) |
| Paul Benedict | Prof. Brainiac |
| Dina Waters | Bambi Madison (as Dina Spybey) |
| Pauline Little | Leslie Barnett |
| William Hill | Passerby |
| Mal Z. Lawrence | Mort |
| Adam Heller | Howie |
| Ellen David | Sylvia |
| Dan Ziskie | Guy's doctor (as Daniel Ziskie) |
| Anna Lobell | Receptionist |
| David Costabile | Junior editor |
| Brett Gillen | Man with bicycle |
| Olga Merediz | Mrs. Ramirez |
| Jacklin Webb | Nurse |
| Clebert Ford | Claude |
| Dick Henley | Doorman |
| Sonia Benezra | Manicurist |
| Richard Litt | Buddy |
| Maurice Carlton | Orderly #1 |
| Edward B. Goldstein | Eddie in Lindy's |
| Larry Block | Herbie |
| Jack Eagle | Waiter |
| Le Clanché du Rand | Lissy Hastings |
| Elizabeth Lawrence | Mimsy Hastings |
| Helen Stenborg | Aunt Abigail |
| John Cunningham | Nelson Hastings |
| Charles S. Doucet | Teamster (as Charles Doucet) |
| John Sanford Moore | Bob Shawcross (as John Moore) |
| Richard McConomy | Harry Gladrey |
| Lisa Bronwyn Moore | Irma Gladrey |
| Steven McCarthy | Book Nook clerk |
| James Villemaire | Jim Morrison |
| Karyn Quackenbush | TV cook |
| Sam Street | Truman Capote |
| Peter Blaikie | David |
| Sheena Larkin | Saleswoman |
| Frank Vincent | Aristotle Onassis |
| David Lawrence | Steve Lawrence |
| Debbie Shapiro Gravitte | Eydie Gorme (as Debbie Gravitte) |
| Mickey Toft | Guy at 6 |
| Ricky Mabe | Guy at 14 |
| Robin Wilcock | Stage murderer (as Robin Andrew Wilcock) |
| Jude Beny | Skeptical housewife |
| Jean-Guy Bouchard | Wolf-whistle Teamster |
| Carl Alacchi | Orderly #2 |
| James Brown | Himself (archive footage) (uncredited) |
| Johnny Carson | Himself (archive footage) (uncredited) |
| Liza Case | Woman reading book in park (uncredited) |
| Dawn Douglas | Moviegoer (uncredited) |
| Patty Duke | Neely O'Hara in 'Valley of the Dolls' (archive footage) (uncredited) |
| Julia Garland | Autistic Child (uncredited) |
| Susan Hayward | Helen Lawson in 'Valley of the Dolls' (archive footage) (uncredited) |
| Marlon Sterling Long | Doorman (uncredited) |
| Antonio Maltese | Extra (uncredited) |
| Nick Stellate | Cop (uncredited) |
