| Scott Bakula | Captain Jonathan Archer / ... (98 episodes, 2001-2005) |
| John Billingsley | Dr. Phlox (98 episodes, 2001-2005) |
| Jolene Blalock | Sub-Commander T'Pol / ... (98 episodes, 2001-2005) |
| Dominic Keating | Lieutenant Malcolm Reed / ... (98 episodes, 2001-2005) |
| Anthony Montgomery | Ensign Travis Mayweather / ... (98 episodes, 2001-2005) |
| Linda Park | Ensign Hoshi Sato / ... (98 episodes, 2001-2005) |
| Connor Trinneer | Commander Charles 'Trip' Tucker III (98 episodes, 2001-2005) |
| Mark Correy | Engineer Alex (43 episodes, 2001-2005) |
| Vaughn Armstrong | Admiral Maxwell Forrest / ... (18 episodes, 2001-2005) |
| Cynthia Uhrich | Starfleet Officer (15 episodes, 2001-2002) |
| Gary Graham | Vulcan Ambassador Soval / ... (12 episodes, 2001-2005) |
| Glen Hambly | Andorian Bridge Officer / ... (12 episodes, 2003-2005) |
| Randy Oglesby | Degra / ... (11 episodes, 2001-2004) |
| Jeffrey Combs | Commander Shran / ... (11 episodes, 2001-2005) |
| Rick Worthy | Jannar (10 episodes, 2003-2004) |
| Dorenda Moore | Private S. Money / ... (10 episodes, 2003-2005) |
| Paul Sklar | MACO Corporal R. Richards / ... (10 episodes, 2003-2005) |
| Tucker Smallwood | Xindi-Primate Councilor / ... (9 episodes, 2003-2004) |
| John Fleck | Silik (8 episodes, 2001-2004) |
| Matt Winston | Temporal Agent Daniels (8 episodes, 2001-2004) |
| Scott MacDonald | Commander Dolim (8 episodes, 2003-2004) |
| James Horan | Humanoid Figure (6 episodes, 2001-2003) |
| Solomon Burke Jr. | Billy / ... (6 episodes, 2001-2005) |
| Eric Pierpoint | Harris / ... (5 episodes, 2002-2005) |
| Steven Culp | Major Hayes (5 episodes, 2003-2004) |
| Derek Magyar | Commander Kelby / ... (5 episodes, 2005) |
| Jim Fitzpatrick | Commander Williams (5 episodes, 2001-2004) |
| Duncan K. Fraser | Ensign Walsh / ... (5 episodes, 2003-2005) |
| Sean McGowan | Corporal Hawkins / ... (4 episodes, 2003-2004) |
| Josette DiCarlo | Sphere-Builder Woman (4 episodes, 2004) |
| J. Michael Flynn | Nijil / ... (4 episodes, 2002-2005) |
| Brent Spiner | Dr. Arik Soong / ... (4 episodes, 2004-2005) |
| Robert Foxworth | Administrator V'Las (3 episodes, 2004) |
| Alec Newman | Malik (3 episodes, 2004) |
| Kellie Waymire | Crewman Elizabeth Cutler (3 episodes, 2001-2002) |
| Abby Brammell | Persis (3 episodes, 2004) |
| John Rubinstein | Minister Kuvak / ... (3 episodes, 2002-2004) |
| Joseph Will | Crewman Michael Rostov (3 episodes, 2002-2003) |
| Molly Brink | Lieutenant Talas (3 episodes, 2004-2005) |
| Daniel Dae Kim | Corporal Chang (3 episodes, 2003-2004) |
| Michael Reilly Burke | Koss (3 episodes, 2004) |
| Brian Thompson | Admiral Valdore (3 episodes, 2005) |
| Ada Maris | Captain Erika Hernandez (3 episodes, 2004-2005) |
| Bruce Thomas | Xindi-Reptilian Soldier (3 episodes, 2004) |
| Andrew Borba | Xindi-Reptilian Lieutenant (3 episodes, 2004) |
| J. Paul Boehmer | Mestral / ... (3 episodes, 2002-2004) |
| Mary Mara | Sphere-Builder Presage (3 episodes, 2004) |
| Ruth Williamson | Sphere-Builder Primary (3 episodes, 2004) |
| Thom Williams | Klingon / ... (3 episodes, 2004) |
| Tracey Kimball | Alien / ... (3 episodes, 2001-2002) |
| Marti Matulis | Reman Bodyguard / ... (3 episodes, 2003-2005) |
| Scott L. Treger | Xindi-Insectoid / ... (3 episodes, 2003-2004) |
| Aaron White | MACO Soldier (3 episodes, 2005) |
| Golden Brooks | Alicia Travers (2 episodes, 2004) |
| Harry Groener | Nathan Samuels (2 episodes, 2005) |
| Conor O'Farrell | Burzaan / ... (2 episodes, 2002-2004) |
| Matt Kaminsky | Crewman Cunningham / ... (2 episodes, 2002-2003) |
| Gregory Itzin | Admiral Black / ... (2 episodes, 2002-2005) |
| Jack Gwaltney | Vosk (2 episodes, 2004) |
| Lee Arenberg | Tellarite Ambassador Gral (2 episodes, 2005) |
| James Avery | General K'Vagh (2 episodes, 2005) |
| John Schuck | Antaak (2 episodes, 2005) |
| Tommy 'Tiny' Lister | Klaang (2 episodes, 2001) |
| Jeff Ricketts | Alien Captain / ... (2 episodes, 2001) |
| Mark Rolston | Captain Magh / ... (2 episodes, 2003-2004) |
| Steven Dennis | Tholos (2 episodes, 2001-2002) |
| Christopher Shea | Andorian Captain Telev / ... (2 episodes, 2002-2003) |
| Bob Morrisey | Dr. Strom / ... (2 episodes, 2003-2004) |
| Philip Boyd | Com Officer (2 episodes, 2003) |
| Richard Riehle | Dr. Jeremy Lucas (2 episodes, 2004) |
| Danny Goldring | Alien Captain / ... (2 episodes, 2001-2002) |
| J.G. Hertzler | Advocate Kolos / ... (2 episodes, 2003-2004) |
| Joanna Cassidy | T'Les (2 episodes, 2004) |
| Brad Greenquist | Captain Khata'n Zshaar / ... (2 episodes, 2003-2005) |
| Daniel Riordan | Duras (2 episodes, 2003) |
| Peter Mensah | Daniel Greaves (2 episodes, 2005) |
| Geno Silva | Senator Vrax (2 episodes, 2005) |
| Thomas Kopache | The Alien / ... (2 episodes, 2001-2004) |
| Mark Moses | Henry Archer (2 episodes, 2001) |
| Tom Bergeron | Alien Trader D'Marr / ... (2 episodes, 2002-2005) |
| Elizabeth Magness | Female Crewmember / ... (2 episodes, 2002) |
| Granville Van Dusen | Andorian General / ... (2 episodes, 2003-2004) |
| Adam Clark | Josiah (2 episodes, 2005) |
| Terrell Tilford | Marab (2 episodes, 2005) |
| Josh Drennen | Degra's Assistant / ... (2 episodes, 2004) |
| Nathan Anderson | Sergeant Kemper (2 episodes, 2003) |
| Kara Zediker | T'Pau (2 episodes, 2004) |
| Kevin Brief | Naarg (2 episodes, 2005) |
| Adam Grimes | Lokesh (2 episodes, 2004) |
| Christopher Neame | German General (2 episodes, 2004) |
| Adam Taylor Gordon | Sim Trip at 8 / ... (2 episodes, 2003) |
| Johanna Watts | Gannet Brooks (2 episodes, 2005) |
| Seth MacFarlane | Engineer / ... (2 episodes, 2004-2005) |
| Steve Schirripa | Carmine (2 episodes, 2004) |
| Majel Barrett | Computer / ... (2 episodes, 2005) |
| Scott Rinker | Gareb / ... (2 episodes, 2005) |
| Ken Lally | Lt. Taylor (2 episodes, 2003) |
| Jack Donner | Vulcan Priest (2 episodes, 2004) |
| Marty Davis | Young Archer (2 episodes, 2001) |
| Peter Weller | John Frederick Paxton (2 episodes, 2005) |
| Dennis Cockrum | Alien Barkeep / ... (2 episodes, 2002) |
| Rudolph Willrich | Captain Kuulan / ... (2 episodes, 2002-2005) |
| Steve Rankin | Colonel Green (2 episodes, 2005) |
| Alexander Xavier Ponce-Bonano | Miner #6 / ... (2 episodes, 2001-2005) |
| Vince Deadrick Jr. | Crewman on Fire / ... (2 episodes, 2002-2004) |
| Baron Jay | Starfleet Crewman (2 episodes, 2002) |
| Kevin Derr | Corporal Kelly / ... (2 episodes, 2003-2004) |
| Erin Leigh Price | Elizabeth Tucker (2 episodes, 2003-2004) |
| Fernando Chien | Saul (2 episodes, 2004) |
| Mischa Pfister | Additional Voices (2 episodes, 2004) |
| Amy Earhart | Vulcan Delegate (2 episodes, 2005) |
| Chase Hoyt | Starfleet Commander (2 episodes, 2005) |
| Trey Stokes | Tellarite Delegate (2 episodes, 2005) |
