| Denzel Washington | Detective Keith Frazier |
| Clive Owen | Dalton Russell |
| Jodie Foster | Madeleine White |
| Christopher Plummer | Arthur Case |
| Willem Dafoe | Captain John Darius |
| Chiwetel Ejiofor | Detective Bill Mitchell |
| Carlos Andrés Gómez | Steve |
| Kim Director | Stevie |
| James Ransone | Steve-O |
| Bernie Rachelle | Chaim (as Bernard Rachelle) |
| Peter Gerety | Captain Coughlin |
| Victor Colicchio | Sergeant Collins |
| Cassandra Freeman | Sylvia |
| Peter Frechette | Peter Hammond |
| Gerry Vichi | Herman Gluck |
| Waris Ahluwalia | Vikram Walia |
| Rafael Osorio | Bank Guard |
| Rodney 'Bear' Jackson | Bank Guard |
| Daryl Mitchell | Mobile Command Officer Rourke (as Daryl 'Chill' Mitchell) |
| Ashlie Atkinson | Mobile Command Officer Berk |
| David Brown | Mobile Command Officer Carnow |
| Robert C. Kirk | Mobile Command Officer Borinsky |
| Frank Stellato | Mobile Command Detective |
| Ken Leung | Wing |
| Marcia Jean Kurtz | Miriam Douglas |
| Ed Onipede Blunt | Ray Robinson |
| Amir Ali Said | Brian Robinson |
| Lemon | Paul Guitierez (as Lemon Andersen) |
| Samantha Ivers | Nancy Mann |
| Peter Kybart | Mayor |
| Jason Manuel Olazabal | ESU Officer Hernandez |
| Jeff Ward | ESU Officer Jesus |
| Anthony Mangano | ESU Officer |
| Michael Devine | ESU Officer |
| Ed Bogdanowicz | ESU Officer |
| Aaron Vexler | ESU Officer |
| Anthony Borowiec | ESU Officer |
| Joe Coots | ESU Officer |
| Lionel Pina | Cop with Pizzas |
| Ken Ferrigni | Redheaded Detective |
| Frank Hopf | Barricade Officer |
| Robert Testut | Barricade Officer |
| Craig M. Spitzer | Seth Greenblatt (as Craig Marcus Spitzer) |
| Limary Agosto | Gladys Perez (as Lily Agosto) |
| Patrick Illig | Brad Stone |
| Frank Composto | Eric Dodge |
| Rozanne Sher | Hostage Woman |
| Rachel Black | Katherine (as Rachel Matthews Black) |
| Gregory Dann | Case's Bodyguard |
| Ben Crowley | White's Assistant |
| Shon Gables | CBS News Reporter |
| Dominic Carter | NY1 News Anchor |
| Sandra Endo | NY1 News Reporter |
| Kandiss Edmundson | Madge |
| Al Palagonia | Kevin |
| Florina Petcu | Ilina |
| Agim Coma | Borova |
| John Speredakos | Officer Porcario |
| Baktash Zaher | Zahir (as Baktash Khadem Zaher) |
| Ernest Rayford | Men's Club Attendant |
| Vincent DiMartino | Barber |
| Julian Niccolini | Four Seasons Maitre d' |
| Ed Crescimanni | Edwin |
| Brad Leland | Ronnie (as Bradley Williams) |
| Tiffany Adams | Hostage (uncredited) |
| Kisha Batista | Hostage (uncredited) |
| Robert Bizik | Business Executive (uncredited) |
| Cherise Boothe | Jeanette Davis - Bank Employee (uncredited) |
| John Borras | ESU Cop (uncredited) |
| Rebecca Brillhart | Four Seasons Server (uncredited) |
| Jay Charan | Teller (uncredited) |
| Stany Coppet | Businessman (uncredited) |
| Ed Cuffe | NYPD Detective (uncredited) |
| Michael Den Dekker | Judge Pasqua (uncredited) |
| Joanie Ellen | Faye Spencer (uncredited) |
| Edwin Freeman | ESU Officer (uncredited) |
| Chuck Gerena | ESU Officer / Ambulance Driver (uncredited) |
| Rashaad Ernesto Green | Matthew Jones (Hostage) (uncredited) |
| Carla Greene | Maria Luna (uncredited) |
| Turi Haim | Cop (uncredited) |
| James Hook | Security Guard (uncredited) |
| Enver Hoxha | Himself (archive sound) (uncredited) |
| Van Hughes | James Curran (uncredited) |
| Matt Jade | ESU Officer (uncredited) |
| Julie Jei | Wall Street Business Woman (uncredited) |
| Russ Klein | Defense Attorney (uncredited) |
| Steve Lord | ESU Officer (uncredited) |
| Heather Male | Katarina Anderson (uncredited) |
| Dominick Mancino | Locksmith (uncredited) |
| John B. Nelson Jr. | Pedestrian (uncredited) |
| Amanda Pennington | Bank Employee (uncredited) |
| James Donnell Quinn | Hostage Irving Levine (uncredited) |
| Jamieson Rhyme | Denis Lenford - Hostage (uncredited) |
| Michal Sinnott | Lori Minitte (uncredited) |
| Alexander Sovronsky | Civilian Bystander (uncredited) |
| Brandhyze Stanley | NY 1 Reporter (uncredited) |
| Philippe Vonlanthen | ESU Officer (uncredited) |
| Angel Wallace | Sandra Velez- Hostage (uncredited) |
| Steven Weisz | Wall Street Businessman (uncredited) |
