| Tom Cruise | Roy Miller |
| Cameron Diaz | June Havens |
| Peter Sarsgaard | John Fitzgerald |
| Jordi Mollà | Antonio Quintana |
| Viola Davis | Isabel George - C.I.A. Director |
| Paul Dano | Simon Feck |
| Falk Hentschel | Bernhard |
| Marc Blucas | Rodney |
| Lennie Loftin | Braces |
| Maggie Grace | April Havens |
| Rich Manley | Danny |
| Dale Dye | Frank Jenkins |
| Celia Weston | Molly Knight |
| Gal Gadot | Naomi |
| Jack O'Connell | Wilmer (as Jack A. O'Connell) |
| Trevor Loomis | Eduardo |
| Nilaja Sun | Allison |
| Tommy Nohilly | Randy Mechanic |
| Taylor Treadwell | Gate Agent |
| Christian Finnegan | Ticket Agent |
| Nicholas Art | Kid at Airport (as Nicholas Reese Art) |
| Brian Dykstra | TSA Officer |
| Brian Tarantina | Scrap Yard Man |
| Natasha Paczkowski | Petra The Tailor |
| Jerrell Lee | Fireman Paul |
| Matthew Lawler | Passerby Agent |
| Ronn Surels | Flight Attendant |
| Eric Robert Bradshaw Bennett | 18 Wheeler Driver |
| Scott Wahle | Newscaster |
| Sara Jean Underwood | Newscaster #2 (as Sara Underwood) |
| Helen L. Welsh | Neighbor |
| King Orba | Smuggler |
| Adam Gregor | Train Cook |
| Mitch E. Bowan | Medivac EMT |
| Gerry Carbajal | Doctor In Hallway (as Gerald T. Carbajal) |
| Michael Enright | Engineer |
| Diana Afonso | Restaurant Patron (uncredited) |
| Charlie Alejandro | Soldier at Airport (uncredited) |
| Carl Alleyne | Groomsman (uncredited) |
| Brian Bradbury | Restaurant Patron (uncredited) |
| Catherine Burt | Waitress (uncredited) |
| Katelyn Cahill | Bridesmaid (uncredited) |
| Desiree April Connolly | Pedestrian / Commuter (uncredited) |
| Jeffrey Corazzini | Automotive Technician (uncredited) |
| D.W. Cormier | Airport Vendor (uncredited) |
| Holland Diaz | Plane Agent (uncredited) |
| Sean Patrick Doherty | State Trooper (uncredited) |
| Paul Elicone | Busboy (uncredited) |
| Susan Farese | Woman in Airport Pub (uncredited) |
| Keith Fluker | Agent (uncredited) |
| Shawn Fogarty | Airport Traveler (uncredited) |
| Hugo Garcia | Bull Runner (uncredited) |
| Suzanne Gillies | Airport Ticket Agent (uncredited) |
| Gina Hernandez | Woman on Escalator (uncredited) |
| Mark Hetherington | Downtown Pedestrian (uncredited) |
| Frankie Imbergamo | Restaurant Patron (uncredited) |
| Stanis Johnson | Precision Driver (uncredited) |
| Georgina Keajra | Airport Girlfriend (uncredited) |
| Ren Knopf | Pedestrian (uncredited) |
| Erica LaRose | Dizzy Day (uncredited) |
| Conan Marchi | Restaurant Patron (uncredited) |
| Dan Marshall | Restaurant Patron (uncredited) |
| Jeff Martineau | U.S. Army Private (uncredited) |
| Olivier Martinez | Beach Scene (uncredited) |
| Robert Masiello | Guest at Grille (uncredited) |
| Erica McDermott | Bridesmaid (uncredited) |
| Peter Motson | (uncredited) |
| Scott Neufville | Bus Passenger (uncredited) |
| Greg Paul | Airport Police / Fire / EMT (uncredited) |
| Donna Glee Reim | Bus Rider (uncredited) |
| Tony Sagastizado I | Bull Runner (uncredited) |
| Nicole Signore | Wedding Guest (uncredited) |
| Michael Stavrinos | Undercover Agent / GTO Chase Scene (uncredited) |
| Stream | Witchita Airport Traveller (uncredited) |
| George J. Vezina | Construction Worker (uncredited) |
| Stephanie Worth | Rodney's Girl (uncredited) |
